MOTS-c — 10mg
189.99€
SS-31 — 10mg
A tetrapeptide that concentrates over 1,000-fold inside mitochondria by binding cardiolipin, the lipid that holds the inner membrane's energy-producing machinery together.
199.99€
Price per vial · Ex Tax 199.99€
- In Stock
- Evidence tier: Emerging
- Format: Lyophilized
- Purity: 99.3%
- Vial size: 10mg
For laboratory research use only. Not for human or veterinary use.
About SS-31
SS-31 (elamipretide) is a synthetic tetrapeptide that selectively concentrates in the inner mitochondrial membrane, where it interacts with cardiolipin — a phospholipid essential for electron transport chain function. It is the most advanced mitochondrial-targeted peptide in clinical development, with published data from multiple Phase 2 and Phase 3 trials. Researchers study SS-31 because it addresses mitochondrial dysfunction at the structural level, not just the signaling level.
SS-31 (elamipretide) is a synthetic tetrapeptide that selectively concentrates in the inner mitochondrial membrane, where it interacts with cardiolipin — a phospholipid essential for electron transport chain function. It is the most advanced mitochondrial-targeted peptide in clinical development, with published data from multiple Phase 2 and Phase 3 trials. Researchers study SS-31 because it addresses mitochondrial dysfunction at the structural level, not just the signaling level.
SS-31 (D-Arg-Dmt-Lys-Phe-NH2, also known as elamipretide/MTP-131/Bendavia) is a synthetic tetrapeptide that concentrates >1,000-fold in mitochondria due to electrostatic attraction between its positively charged arginine/lysine residues and negatively charged cardiolipin in the inner mitochondrial membrane (IMM). It stabilizes cardiolipin-dependent cristae structure, enhances electron transport chain (ETC) efficiency (particularly Complex III and IV), improves cytochrome c electron-carrying activity while reducing its peroxidase activity, scavenges reactive oxygen species, increases ATP production, and inhibits mitochondrial permeability transition pore (mPTP) opening. This prevents calcium overload and cytochrome c release (anti-apoptotic).
Mechanism clarity: Well-characterized
Tags
Key takeaways
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Research score 8/10
300+ published studies in the dataset
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Evidence tier: Emerging
Emerging — Active clinical trials (Barth syndrome Phase 2/3, heart failure, kidney disease). Published in top journals (PNAS, Nature, eLife). Mechanism is well-characterized. Not yet FDA-approved but multiple clinical programs running. More human data than most peptides on this list (excluding approved ones).
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Human data
Phase 2/3 clinical trials
Storage and handling
Lyophilised powder: Room temp or refrigerated
After reconstitution: Refrigerate, use within 28 days
Safety and limitations
Studied for: Mitochondrial function, Anti-aging, Energy restoration, Cardiac support, Neuroprotection
Reported onset: Initial fatigue common in first 1-2 weeks (resolves); energy improvements by weeks 3-4
Reported duration: 4-8 weeks; 2-5mg SC daily, 5 days on/2 off
Community reports: Initial fatigue/malaise is the most-discussed side effect — community recommends methyl donor supplementation (B12, betaine, glycine). After the adaptation period, users report significant energy improvements. Commonly paired with MOTS-c and NAD+. One user on r/BodyHackGuide called high-dose SS-31 + Epithalon 'best decision I ever made.'
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Quality and specifications
Product details
- Product code
- L-SS31-10
- Availability
- In Stock
- Evidence tier
- Emerging
- Format
- Lyophilized
- Purity
- 99.3%
- Vial size
- 10mg
Reconstitution reference
- Bacteriostatic water
- 2 mL
- Concentration
- 50mcg per unit (0.01mL). 2mg dose = 40 units.
- Syringe
- 29-31G insulin
Research parameters
- Standard amount
- 2000 µg
- Alternative amount
- 5000 µg
- Vial
- 10 mg
- Dataset estimate
- 1 vial lasts ~1 week at 2mg/day (5 on/2 off)
Lab report record
- Laboratory
- Janoshik Analytical
- Test date
- 2026-03-01
- Document
- PDF not attached
See the science
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PMID 19064528
Read study: SS-31 and mitochondrial dysfunction (opens in a new tab)
SS-31 and mitochondrial dysfunction
Restored mitochondrial function and reduced oxidative stress in aged cardiac tissue.
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PMID 26675167
Read study: Elamipretide in heart failure (opens in a new tab)
Elamipretide in heart failure
Improved cardiac function in heart failure patients in Phase II clinical trials.
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PMID 32817602
Read study: Mitochondrial protein interaction landscape of SS-31 (PNAS) (opens in a new tab)
Mitochondrial protein interaction landscape of SS-31 (PNAS)
SS-31 primarily interacts with cardiolipin in the inner mitochondrial membrane; comprehensive interaction map reveals direct ETC stabilization.
Studies are listed for reference. Most were carried out in animal or cell models; their findings do not establish safety or effect in humans.
Further reading
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 10-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
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1 year agor/cfs · Post
I've been taking SS-31 for about 4-5 months with some minor breaks. … My primary reason for taking it is to improve egg quality during IVF .
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11 months agor/cfs · Post
SS31 … injecting … this feeling returned, again 3 hours after injection, but intensified
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10 months agor/Peptides · Post
I started today on ss-31 today knowing I'm very sensitive to substances, so decided to start on 0.1mg. … I feel a bit of restlessness and the weird part it feels like I can inhale more air...kind of like as if my air passage has widened.
Based on 3 qualifying reports from 3 threads. 32 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Questions about SS-31
Questions and answers recorded for this product.
The initial fatigue/malaise effect is well-documented in the community and typically lasts 1-2 weeks before resolving. It may relate to mitochondrial remodeling as dysfunctional mitochondria are cleared. Community recommends methyl donor supplementation (B12, betaine, glycine) and starting at lower doses (2mg/day).
Both target mitochondria but through different mechanisms. SS-31 stabilizes the electron transport chain directly, while MOTS-c activates AMPK and metabolic pathways.
Yes. As elamipretide, it is in clinical trials for Barth syndrome and other mitochondrial diseases. It has FDA Rare Pediatric Disease and Breakthrough Therapy designations.
Reviews
There are no reviews for this product yet.
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SS-31 — 50mg
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