Intermediate · 4-8 weeks

SS-31 Mitochondrial Support

Daily SS-31 (Elamipretide) for mitochondrial membrane stabilization via cardiolipin binding. Start at 10mg and ramp to therapeutic dose. Phase 2/3 clinical trials support long-term safety.

Type: single
Source: evidence-based
Pattern: 8-12 weeks on, 4 weeks off

Compounds

SS-31
SC · Morning or any consistent time. Rapidly absorbed (peak 30-60 min).

20 mg
daily

Phases

Ramp-Up
Weeks 1

10
Start at 10mg daily to assess tolerance

Full Dose
Weeks 2-8

20
20mg daily

Notes

Supply: 5mg vials at 20mg/day = need 4 vials/week → 6 vials for ramp week + partial second week. Well tolerated in clinical trials at 40mg/day for up to 5 years.

Source notes

Phase 2/3 trials for mitochondrial myopathy: Neurology 2018 (PMID: 29549222). FDA Fast Track designation. International Peptide Society: 40mg SC daily for 12-24 weeks. Dr. Iman Bar: Peak Performance Protocol.

For research and educational use only. This content is not medical advice.