Ipamorelin — 10mg
159.99€
Sermorelin Acetate — 10mg
The first 29 amino acids of your body's own growth hormone-releasing hormone, retaining full biological activity while preserving the pituitary feedback loop that exogenous GH shuts down.
234.99€
Ex Tax 234.99€
- In Stock
- Evidence tier: Established
- Format: Lyophilized
- Purity: 99.4%
- Vial size: 10mg
For laboratory research use only. Not for human or veterinary use.
About Sermorelin Acetate
Sermorelin acetate is a synthetic peptide consisting of the first 29 amino acids of human growth hormone-releasing hormone (GHRH 1-29). It is the shortest fully functional fragment of GHRH and has been extensively studied for its ability to stimulate natural, pulsatile growth hormone release from the pituitary. With decades of published clinical data, sermorelin remains the benchmark GHRH analog for growth hormone axis research.
Sermorelin acetate is a synthetic peptide consisting of the first 29 amino acids of human growth hormone-releasing hormone (GHRH 1-29). It is the shortest fully functional fragment of GHRH and has been extensively studied for its ability to stimulate natural, pulsatile growth hormone release from the pituitary. With decades of published clinical data, sermorelin remains the benchmark GHRH analog for growth hormone axis research.
Sermorelin is a synthetic 29-amino acid peptide corresponding to the N-terminal segment of GHRH(1-44) that retains full biological activity at GHRH receptors. It stimulates GH gene transcription, increases pituitary GH reserve, and promotes pulsatile GH secretion by activating GHRH-R on somatotrophs via cAMP/PKA signaling. Critically, it preserves the hypothalamic-pituitary GH neuroendocrine axis (the first axis to decline with aging). By supporting pituitary function rather than bypassing it, sermorelin maintains physiological feedback mechanisms including somatostatin regulation.
Mechanism clarity: Well-characterized
Tags
Key takeaways
-
Research score 9/10
284+ published studies in the dataset
-
Evidence tier: Established
Established — Previously FDA-approved (Geref). Extensive clinical data. Most widely prescribed peptide in anti-aging medicine via compounding pharmacies. Well-understood mechanism with decades of use.
-
Human data
Previously FDA-approved (Geref); extensive clinical data in aging and GH deficiency
Storage and handling
Lyophilised powder: Room temperature or refrigerated
After reconstitution: Refrigerate; use within 30 days
Safety and limitations
Studied for: Anti-aging and GH optimization, Sleep quality improvement, Body composition improvement, Recovery from exercise, Energy and vitality enhancement
Reported onset: Sleep improvement within 1-2 weeks; body composition changes over 2-3 months
Reported duration: 3-6 months; 200-500mcg SC daily before bedtime
Community reports: Considered the 'safe, boring, reliable' GH peptide. Anti-aging clinic staple. Users report gradual improvements in sleep, skin quality, and body composition over 2-3 months. Natural feedback prevents GH excess. Often recommended as starting point before moving to ipamorelin or CJC combinations.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Quality and specifications
Product details
- Product code
- L-SERM-10
- Availability
- In Stock
- Evidence tier
- Established
- Format
- Lyophilized
- Purity
- 99.4%
- Vial size
- 10mg
Reconstitution reference
- Bacteriostatic water
- 2 mL
- Concentration
- 5mg/mL (5mcg per unit). Standard 300mcg dose = 60 units (0.06mL).
- Syringe
- 29-31G insulin
Research parameters
- Standard amount
- 300 µg
- Alternative amount
- 500 µg
- Vial
- 10 mg
- Dataset estimate
- ~4.7 weeks at 300mcg/day (1 vial of 10mg)
Lab report record
- Laboratory
- Janoshik Analytical
- Test date
- 2026-03-01
- Document
- PDF not attached
See the science
-
PMID 11337753
Read study: GHRH analogs in aging (opens in a new tab)
GHRH analogs in aging
Sermorelin increased IGF-1 and improved body composition markers in older adults.
-
PMID 9467534
Read study: Sermorelin and growth hormone deficiency (opens in a new tab)
Sermorelin and growth hormone deficiency
Demonstrated effective GH stimulation with preserved physiological pulsatility.
-
PMID 19528064
Read study: Sermorelin: a better approach to management of adult-onset GH insufficiency (opens in a new tab)
Sermorelin: a better approach to management of adult-onset GH insufficiency
Sermorelin stimulates GH gene transcription, preserves the GH neuroendocrine axis, and maintains pituitary reserve — advantages over exogenous GH replacement.
-
Sermorelin and pituitary reserve in aging
Preserves GH axis during aging better than exogenous GH. Pulsatile GH release pattern maintained, supporting physiological feedback mechanisms including somatostatin regulation.
Studies are listed for reference. Most were carried out in animal or cell models; their findings do not establish safety or effect in humans.
Further reading
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 10-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
-
6 months agor/BodyHackGuide · Post
Sermorelin … started taking sermorelin … massive difference in sleep, mood, energy levels, and performance in the gym
-
1 year agor/PeptideForum · Post
Semorelin … I have been on Semorelin since March 2024 … fat loss, muscle growth, increased strength and stamina, more clarity in my thoughts, and just a more positive attitude
Based on 2 qualifying reports from 2 threads. 47 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Questions about Sermorelin Acetate
Questions and answers recorded for this product.
Sermorelin works through the GHRH receptor pathway, while ipamorelin works through the ghrelin/GHS receptor pathway — two completely different mechanisms for stimulating GH release. Sermorelin has deeper clinical data (previously FDA-approved) and is considered more established. Ipamorelin is more selective with fewer side effects. Many researchers study both together for synergistic GH release through dual-pathway stimulation.
Sermorelin was FDA-approved as Geref Diagnostic in 1997 and withdrawn from the US market in 2008. The withdrawal was for commercial/business reasons (low profitability), NOT for safety concerns. Sermorelin continues to be widely prescribed through compounding pharmacies and remains the most prescribed peptide in anti-aging medicine.
Sermorelin is most commonly administered before bed on an empty stomach (2-3 hours after eating). This timing amplifies the natural nocturnal GH pulse that occurs during deep sleep. Food — particularly carbohydrates and fats — can blunt GH release. Some protocols include up to 1mg nightly for clinical applications.
Sermorelin stimulates your pituitary to release its own GH, preserving natural pulsatile patterns and feedback loops. Exogenous HGH bypasses and suppresses this system.
Yes. Sermorelin acetate was FDA-approved as Geref® for diagnostic evaluation and treatment of growth hormone deficiency. It has one of the strongest clinical track records of any research peptide.
Reviews
There are no reviews for this product yet.
Related products
-
-
Tesamorelin — 10mg
279.99€
How ordering works
Product details, references and your order stay connected.
-
Choose the compound
Pick a compound and vial size in the catalogue.
-
Review product information
Open the product details and supporting research.
-
Keep the references
Save the source references for your records.
Why order from PeptidesEuro
Compound profiles
Structure, available sizes and handling notes on one record.
Study references
Product pages link to the studies behind each compound.
One order record
Orders and their details stay in your account.
Clear product data
Price, stock status and tax shown on every product.
PeptidesEuro is a research materials supplier operated by Pepticore LLC. We provide high-purity peptides and research compounds for in-vitro laboratory and scientific research purposes. All products are sold strictly for research use only and are not intended for human or animal consumption.
No. All products sold through meimx.com are intended strictly for in-vitro laboratory and scientific research purposes only. They are not intended for human or animal consumption, injection, ingestion, inhalation, or any form of administration to living organisms. By purchasing from PeptidesEuro, you acknowledge and agree to these terms as outlined in our Terms of Service.
No. Our products have not been evaluated, approved, or authorized by the U.S. Food and Drug Administration (FDA) or any other regulatory body. They are not intended to diagnose, treat, cure, mitigate, or prevent any disease or medical condition. PeptidesEuro is not a compounding pharmacy or outsourcing facility as defined under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act.
No. PeptidesEuro does not provide medical advice, treatment recommendations, or dosing instructions. Any information on our website, including product descriptions and referenced research, is provided for educational and informational purposes only. If you have medical questions, please consult a licensed healthcare provider.
Research Use Only means that our products are sold exclusively as reference standards and research materials for use in laboratory and scientific research settings. Purchasers agree to use all products solely for legitimate research purposes in compliance with all applicable laws and regulations.
Ready to order Sermorelin Acetate?
Browse the catalogue or answer one question in the product finder.