Beginner · 3-6 months

Sermorelin 5-Day-On Protocol

5 days on, 2 days off pattern to maintain receptor sensitivity during extended cycles. 300mcg bedtime on weekdays, off weekends. For researchers running longer 6-month+ protocols.

Type: single
Source: clinic-standard
Pattern: 5 days on, 2 days off — continuous for 3-6 months

Compounds

Sermorelin
SC · Before bedtime, weekdays only. Empty stomach.

300 mcg
5on-2off

Notes

Weekend breaks help maintain GHRH receptor sensitivity over long cycles. Same total weekly dose as daily × 5 instead of × 7. Some run this continuously for up to 12 months.

Source notes

Clinic standard: multiple clinics prescribe 5 on/2 off for extended duration. r/Peptides: popular long-term protocol.

For research and educational use only. This content is not medical advice.