NAD+ — 500mg
249.99€
MOTS-c — 10mg
The first peptide discovered to be encoded by mitochondrial DNA rather than nuclear DNA, shown to activate the same metabolic pathways as physical exercise.
189.99€
Ex Tax 189.99€
- In Stock
- Evidence tier: Emerging
- Format: Lyophilized
- Purity: 99.3%
- Vial size: 10mg
For laboratory research use only. Not for human or veterinary use.
About MOTS-c
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome's 12S rRNA gene. It is the first mitochondrial-encoded peptide shown in published research to regulate nuclear gene expression — making it a signaling molecule between mitochondria and the cell nucleus. Researchers study MOTS-c for its documented effects on metabolic homeostasis, exercise physiology, and cellular energy production.
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome's 12S rRNA gene. It is the first mitochondrial-encoded peptide shown in published research to regulate nuclear gene expression — making it a signaling molecule between mitochondria and the cell nucleus. Researchers study MOTS-c for its documented effects on metabolic homeostasis, exercise physiology, and cellular energy production.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid peptide encoded by the mitochondrial genome (12S rRNA gene). It is the first mitochondrial-derived peptide (MDP) shown to regulate nuclear gene expression. In response to metabolic stress or exercise, MOTS-c translocates to the nucleus where it regulates antioxidant response element (ARE) genes, activates AMPK signaling, enhances skeletal muscle glucose uptake via GLUT4 translocation, increases fatty acid oxidation, and improves mitochondrial respiration. Functions as an exercise mimetic by activating exercise-responsive gene programs.
Mechanism clarity: Well-characterized (AMPK activation, nuclear translocation, ARE gene regulation)
Tags
Key takeaways
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Research score 7/10
200+ published studies in the dataset
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Evidence tier: Emerging
Experimental — Highly promising preclinical data. Limited human data (small studies, mostly observational correlations). The mitochondrial origin and exercise-mimetic mechanism are scientifically novel and well-published, but clinical translation is early.
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Reality tier: Emerging
Discovered 2015 at USC. Accelerating publication rate. Exercise-mimetic properties confirmed in animal models. Limited human data.
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Human data
Small observational studies; exercise correlation data
Storage and handling
Lyophilised powder: Room temp or refrigerated
After reconstitution: Refrigerate at 2-8°C, use within 14 days
Reconstitution steps from the dataset
- Clean. Remove flip-top cap and swab rubber stopper with alcohol.
- Draw water. Draw 1mL of bacteriostatic water into syringe.
- Inject water. Insert needle through stopper and slowly inject water down the side of the vial.
- Dissolve. Gently swirl until fully dissolved. Solution should be clear.
- Label. Label vial with date and concentration (10mg/mL). Refrigerate immediately.
- Dose. For 5mg dose: draw 0.5mL (50 units). For 10mg dose: draw full 1mL. Inject SC in abdomen.
Safety and limitations
Studied for: Exercise mimetic effects, Insulin sensitivity, Metabolic regulation, Mitochondrial function, Longevity/healthspan
Reported onset: 1-2 weeks for subjective energy changes; 4+ weeks for metabolic effects
Reported duration: 4-8 week cycles; some protocols run 4-6 weeks with breaks
Community reports: Mixed but positive. Some users report clear energy improvement and better workout recovery. Others say effects are subtle without biomarker tracking. Often stacked with SS-31 for "mitochondrial stack." Best results reported with consistent exercise alongside.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Quality and specifications
Product details
- Product code
- L-MOTSC-10
- Availability
- In Stock
- Evidence tier
- Emerging
- Format
- Lyophilized
- Purity
- 99.3%
- Vial size
- 10mg
Reconstitution reference
- Bacteriostatic water
- 1 mL
- Concentration
- 10mg/mL when reconstituted with 1mL. 5mg dose = 0.5mL (50 units). 10mg dose = 1mL (100 units).
- Syringe
- 29-31G insulin syringe (1mL capacity recommended)
Research parameters
- Standard amount
- 5000 µg
- Alternative amount
- 10000 µg
- Vial
- 10 mg
- Dataset estimate
- ~1 week at 10mg 3x/week (1 vial), ~2 weeks at 5mg 3x/week
Lab report record
MOTS-c 10mg — Certificate of Analysis
- Laboratory
- Janein Labs
- Test date
- 2026-03-01
- Status
- Passed
- Recorded purity
- 99.0%
- Endotoxin
- <0.5 EU/mg
- Document
- PDF not attached
See the science
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PMID 25738459
Read study: MOTS-c discovery and metabolic effects (opens in a new tab)
MOTS-c discovery and metabolic effects
Identified MOTS-c as a mitochondrial-derived peptide that regulates metabolic homeostasis and targets insulin resistance.
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PMID 30135581
Read study: MOTS-c and exercise (opens in a new tab)
MOTS-c and exercise
MOTS-c levels increase with exercise and mediate some exercise-induced metabolic adaptations.
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PMID 33082511
Read study: MOTS-c and COVID-19 resilience (opens in a new tab)
MOTS-c and COVID-19 resilience
Higher endogenous MOTS-c levels associated with better metabolic resilience in older adults.
Studies are listed for reference. Most were carried out in animal or cell models; their findings do not establish safety or effect in humans.
Further reading
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 2-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
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6 months agor/BodyHackGuide · Post
I got what I would describe as almost an intense focus
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11 months agor/Peptidesource · Post
Mots C … 1st dose … headaches whenever I inject Mots C. And noticed my dandruff flare up since my 1st dose.
Based on 2 qualifying reports from 2 threads. 23 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Questions about MOTS-c
Questions and answers recorded for this product.
Yes. MOTS-c is encoded in the mitochondrial genome and naturally produced by cells. Levels increase with exercise and decline with age.
A compound that activates some of the same cellular pathways as physical exercise — particularly AMPK activation and metabolic adaptation. MOTS-c is the most studied mitochondrial exercise mimetic.
Growing mainstream media coverage, accelerating research publication rate, and endorsement by prominent longevity researchers have driven rapid demand growth.
Reviews
There are no reviews for this product yet.
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