BPC-157 — 5mg
109.99€
Selank — 10mg
The anxiolytic peptide that modulates GABA without the sedation or dependency.
189.99€
Ex Tax 189.99€
- In Stock
- Evidence tier: Emerging
- Format: Lyophilized
- Purity: 99.3%
- Vial size: 10mg
For laboratory research use only. Not for human or veterinary use.
About Selank
Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin, developed by the Russian Academy of Sciences and approved in Russia for anxiety and cognitive enhancement. Its mechanism — modulating GABAergic signaling without benzodiazepine-like sedation or dependency — has made it one of the most studied anxiolytic peptides in the world. Researchers value Selank for its clean anxiolytic profile with simultaneous nootropic effects.
Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin, developed by the Russian Academy of Sciences and approved in Russia for anxiety and cognitive enhancement. Its mechanism — modulating GABAergic signaling without benzodiazepine-like sedation or dependency — has made it one of the most studied anxiolytic peptides in the world. Researchers value Selank for its clean anxiolytic profile with simultaneous nootropic effects.
Selank is a synthetic heptapeptide analog of tuftsin (Thr-Lys-Pro-Arg), the immunomodulatory fragment of IgG heavy chain, extended with Pro-Gly-Pro at the C-terminus for metabolic stability. Developed at the V.V. Zakusov Research Institute of Pharmacology (Russia). Its anxiolytic mechanism involves concentration-dependent allosteric modulation of GABA-A receptors (comparable to benzodiazepines), modulation of GABAergic gene expression (GABA transaminase, GAD, GABA-A receptor subunits), enhancement of enkephalin-degrading enzyme activity, and immunomodulatory effects via tuftsin-like NK cell and phagocyte activation.
Mechanism clarity: Well-characterized (GABA-A allosteric modulation, GABAergic gene expression, enkephalin metabolism)
Tags
Key takeaways
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Research score 7/10
250+ published studies in the dataset
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Evidence tier: Emerging
Emerging — Approved in Russia with clinical data for GAD. Mechanism well-characterized in peer-reviewed journals. Limited Western clinical trial data. The GABA-A modulation mechanism is well-understood and comparable to established anxiolytic pathways.
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Reality tier: Established
Approved prescription medication in Russia for anxiety. Clinical anxiolytic data comparable to benzodiazepines without sedation/dependence.
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Human data
Russian clinical trials for GAD and neurasthenia; limited Western data
Storage and handling
Lyophilised powder: Room temp or refrigerated
After reconstitution: Refrigerate at 2-8°C, use within 14-21 days
Reconstitution steps from the dataset
- Prepare. If using pre-made nasal spray, skip to step 5. For powder reconstitution: clean vial top with alcohol.
- Add saline. Draw 2mL bacteriostatic saline (NOT water) and inject slowly into vial.
- Dissolve. Gently swirl until fully dissolved. Solution should be clear.
- Transfer. Transfer solution to a sterile nasal spray bottle. Each spray ≈ 0.1mL (200mcg at 5mg/mL).
- Administer. Insert nozzle into nostril and spray. Alternate nostrils. Standard dose: 1-3 sprays (200-600mcg) 2-3x daily. Can also use 1-2 sprays as needed for acute anxiety.
- Store. Refrigerate nasal spray. Use within 14-21 days after reconstitution.
Safety and limitations
Studied for: Generalized anxiety disorder, Neurasthenia, Immune modulation, Cognitive enhancement, Stress resilience
Reported onset: 10-20 minutes intranasal; can be used acutely for situational anxiety
Reported duration: 2-4 week cycles on, 2 weeks off; also used as-needed for acute anxiety
Community reports: More consistently positive than Semax. Users describe "calm focus without sedation." No reports of dependence or withdrawal — a major selling point vs benzodiazepines. N-Acetyl Selank reported as notably more potent. Nasal spray format slightly inconvenient but manageable.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Quality and specifications
Product details
- Product code
- L-SELANK-10
- Availability
- In Stock
- Evidence tier
- Emerging
- Format
- Lyophilized
- Purity
- 99.3%
- Vial size
- 10mg
Reconstitution reference
- Bacteriostatic water
- 2 mL
- Concentration
- Nasal spray: ~200mcg per spray. If reconstituting from powder: 5mg/mL with 2mL bacteriostatic saline.
- Syringe
- Nasal spray bottle (not syringe)
Research parameters
- Standard amount
- 400 µg
- Alternative amount
- 600 µg
- Vial
- 10 mg
- Dataset estimate
- ~8 days at 400mcg 3x/day (1 vial of 10mg)
Lab report record
Selank 10mg — Certificate of Analysis
- Laboratory
- Janein Labs
- Test date
- 2026-03-01
- Status
- Passed
- Recorded purity
- 99.1%
- Endotoxin
- <0.5 EU/mg
- Document
- PDF not attached
See the science
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PMID 18577767
Read study: Selank anxiolytic activity (opens in a new tab)
Selank anxiolytic activity
Demonstrated anxiolytic effects comparable to benzodiazepines without sedation or dependence in clinical studies.
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PMID 19306040
Read study: Selank and GABA modulation (opens in a new tab)
Selank and GABA modulation
Increased GABA-A receptor expression and modulated inhibitory neurotransmission.
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PMID 24129675
Read study: Selank effects on expression of genes encoding GABAergic neurotransmission system (opens in a new tab)
Selank effects on expression of genes encoding GABAergic neurotransmission system
Selank modulates expression of 45 genes related to GABAergic neurotransmission, including GABA transporter, receptor subunits, and synthesis enzymes, confirming its mechanism of anxiolytic action.
Studies are listed for reference. Most were carried out in animal or cell models; their findings do not establish safety or effect in humans.
Further reading
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 2-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
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1 year agor/Nootropics · Post
I started on Prozac in January and it’s helped a lot but I was still fighting it everyday. … I started on Prozac in January and it’s helped a lot but I was still fighting it everyday.
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1 year agor/NootropicsHelp · Post
selank … I took a shot of selank today … bad side effects like headaches, feeling dizzy, stomach discomfort and even mood swing which werent good, like if i was depressed and even anxious (which i thought its actually anxiolytic), back pain from this stress response and histamin…
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5mo agor/BodyHackGuide · Comment
Selank … I just took 2 hits of Selank … I feel amazing
Based on 5 qualifying reports from 5 threads. 20 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Questions about Selank
Questions and answers recorded for this product.
Both Selank and benzodiazepines modulate GABA-A receptors, but through different allosteric sites. Selank also modulates expression of 45+ GABAergic genes (transporter, synthesis, receptor subunits), providing a broader, more physiological regulation. Critically, Selank shows no evidence of tolerance, dependence, or withdrawal syndrome — the major limitations of benzodiazepines.
Yes. Semax and Selank are frequently studied together as complementary nootropics — Semax for focus/energy, Selank for calm/anxiety reduction.
Research indicates Selank does not produce tolerance, dependence, or withdrawal effects — unlike benzodiazepines.
Reviews
There are no reviews for this product yet.
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