Beginner · Continuous while on TRT
hCG TRT Adjunct Standard
Standard hCG protocol for testosterone replacement therapy: 500 IU SC 3x/week. Maintains testicular function, intratesticular testosterone, and fertility while on TRT.
- Type
- single
- Source
- evidence-based
- Pattern
- Continuous while on TRT; standalone: 4-12 week cycles
Compounds
hCG
SC · Any consistent time. Often paired with TRT injection schedule. e.g., M/W/F.
SC · Any consistent time. Often paired with TRT injection schedule. e.g., M/W/F.
500 IU
3x-week
3x-week
Notes
Supply: 5000 IU vial = 10 doses at 500 IU. Need 1 vial per ~3.3 weeks. 2 vials for 8-week course. Monitor estradiol — may need aromatase inhibitor if E2 spikes. IU dosing (not mcg).
Source notes
PMID: 30066624 (hCG for infertility). PMID: 29931087 (hCG monotherapy). 500 IU SC 3x/week maintains intratesticular testosterone. Defy Medical, Gameday Men's Health: 250-500 IU 2-3x/week.
For research and educational use only. This content is not medical advice.