MOTS-c — 10mg
189.99€
NAD+ — 500mg
The coenzyme required for 500+ enzymatic reactions in every living cell, with levels that decline approximately 50% between ages 40 and 60.
249.99€
Ex Tax 249.99€
- In Stock
- Evidence tier: Established
- Format: Lyophilized
- Purity: 99.5%
- Vial size: 500mg
For laboratory research use only. Not for human or veterinary use.
About NAD+
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, essential for mitochondrial energy production, DNA repair, sirtuin activation, and hundreds of other enzymatic reactions. NAD+ levels decline significantly with age — by up to 50% between ages 40 and 60 — and this decline is now considered a hallmark of biological aging. Researchers study NAD+ because replenishing cellular NAD+ addresses one of the most upstream and universal mechanisms of age-related decline.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, essential for mitochondrial energy production, DNA repair, sirtuin activation, and hundreds of other enzymatic reactions. NAD+ levels decline significantly with age — by up to 50% between ages 40 and 60 — and this decline is now considered a hallmark of biological aging. Researchers study NAD+ because replenishing cellular NAD+ addresses one of the most upstream and universal mechanisms of age-related decline.
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme in every living cell, participating in 500+ enzymatic reactions. It serves as an electron carrier in mitochondrial oxidative phosphorylation (energy production), a substrate for sirtuins (SIRT1-7, NAD-dependent deacetylases that regulate cellular aging, DNA repair, inflammation, and metabolism), a substrate for PARPs (poly-ADP-ribose polymerases for DNA repair), and a signaling molecule for CD38-mediated calcium signaling. NAD+ declines with age due to increased CD38 activity, decreased NAMPT expression, and increased DNA damage driving PARP consumption. Subcutaneous NAD+ injection bypasses first-pass metabolism and the absorption limitations of oral precursors (NMN, NR).
Mechanism clarity: Well-characterized
Tags
Key takeaways
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Research score 8/10
1,284+ published studies in the dataset
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Evidence tier: Established
Emerging — NAD+ biology is extremely well-established (Nobel Prize-level science). Clinical use of IV NAD+ has decades of history (addiction medicine since the 1960s). Subcutaneous injection is newer but increasingly common via compounding pharmacies. The gap is in rigorous RCTs specifically for SC NAD+ in healthy aging populations.
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Human data
Small trials
Storage and handling
Lyophilised powder: Room temp or refrigerated
After reconstitution: Refrigerate, use within 30 days
Reconstitution steps from the dataset
- Clean. Remove flip-top cap from NAD+ vial and swab rubber stopper with alcohol.
- Draw water. Draw 2.5mL of bacteriostatic water into syringe.
- Inject water. Insert needle through stopper and slowly inject water down the side of the vial. Do not spray directly onto powder.
- Dissolve. Gently swirl (do not shake) until fully dissolved. Solution should be clear.
- Label. Label vial with date and concentration (200mg/mL). Refrigerate immediately.
- Dose. For 50mg dose: draw 0.25mL (25 units). For 100mg dose: draw 0.5mL (50 units).
Safety and limitations
Studied for: Cellular energy, DNA repair, Sirtuin activation, Mitochondrial function, Anti-aging
Reported onset: 1-2 weeks for subjective energy improvement; 4-8 weeks for full protocol effects
Reported duration: Ongoing supplementation; most protocols reference 4-12 week cycles with breaks
Community reports: Almost universal stinging at injection site. Users recommend icing before/after. Energy and mental clarity improvements frequently reported within first week. Some report vivid dreams.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Quality and specifications
Product details
- Product code
- L-NAD-500
- Availability
- In Stock
- Evidence tier
- Established
- Format
- Lyophilized
- Purity
- 99.5%
- Vial size
- 500mg
Reconstitution reference
- Bacteriostatic water
- 2.5 mL
- Concentration
- 200mg/mL when reconstituted with 2.5mL. 50mg dose = 0.25mL (25 units on insulin syringe).
- Syringe
- 29-31G insulin syringe
Research parameters
- Standard amount
- 50000 µg
- Alternative amount
- 100000 µg
- Vial
- 500 mg
- Dataset estimate
- ~10 days at 50mg/day (1 vial)
Lab report record
- Laboratory
- Janoshik Analytical
- Test date
- 2026-03-01
- Document
- PDF not attached
See the science
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PMID 24360282
Read study: NAD+ and sirtuins in aging (opens in a new tab)
NAD+ and sirtuins in aging
Declining NAD+ levels drive age-related sirtuin dysfunction, contributing to metabolic and neurodegenerative disease.
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PMID 29514064
Read study: NAD+ supplementation in aging (opens in a new tab)
NAD+ supplementation in aging
NAD+ restoration improved mitochondrial function, stem cell renewal, and lifespan in animal models.
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PMID 33037420
Read study: NAD+ in human clinical trials (opens in a new tab)
NAD+ in human clinical trials
Oral NAD+ precursors safely raised blood NAD+ levels and improved physical performance in older adults.
Studies are listed for reference. Most were carried out in animal or cell models; their findings do not establish safety or effect in humans.
Further reading
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 2-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
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1 year agor/NicotinamideRiboside · Post
NAD … I am now taking the injections. … WOW I feel amazing. It's 9:28 PM right now, usually I am bogged down and tired by this time. I feel like I am 20 again.
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4 months agor/NTNPerformance · Post
Injection goes straight in so it’s stronger and you actually feel it more, especially energy wise 1 Continue this thread u/ShaySoda avatar ShaySoda • 2mo ago I mixed the water with the NAD 1ml for every 200mg and when I pinned it burned did anyone else feel this at all 2 u/deadi…
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1 year agor/NicotinamideRiboside · Post
NAD+ … one 50 mg shot of NAD+ … headache for three days
Based on 5 qualifying reports from 5 threads. 28 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Questions about NAD+
Questions and answers recorded for this product.
NAD+ is the active coenzyme that niacin (B3) is used to produce. Niacin is a precursor; NAD+ is the functional molecule.
NAD+ requires significantly higher doses (750mg vs. 5-10mg for most peptides) and has higher synthesis and stability costs.
Oral precursors (NMN, NR) must be converted to NAD+ in the body, with variable absorption. Direct NAD+ administration bypasses conversion steps. Both approaches have research support.
Reviews
There are no reviews for this product yet.
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