Advanced · 24+ weeks
Tirzepatide Maximum Dose Protocol
Full FDA escalation to 15mg weekly maximum. For researchers needing maximum metabolic effect who tolerate GI side effects. Start at 2.5mg, increase 2.5mg every 4 weeks through all dose tiers.
- Type
- single
- Source
- evidence-based
- Pattern
- Continuous
Compounds
Tirzepatide
SC · Weekly, consistent day. Target 15mg after full escalation.
SC · Weekly, consistent day. Target 15mg after full escalation.
15 mg
weekly
weekly
Phases
Initiation
Weeks 1-4
Weeks 1-4
2.5
5mg
Weeks 5-8
Weeks 5-8
5
7.5mg
Weeks 9-12
Weeks 9-12
7.5
10mg
Weeks 13-16
Weeks 13-16
10
12.5mg
Weeks 17-20
Weeks 17-20
12.5
Maximum Dose
Weeks 21+
Weeks 21+
15
15mg weekly — FDA maximum dose
15mg weekly — FDA maximum dose
Notes
Full escalation through all 6 dose tiers. Most researchers settle at 5-10mg — only continue escalating if response at lower dose is inadequate. Monitor for pancreatitis (rare but serious). DO NOT combine with retatrutide.
Source notes
FDA label: max 15mg weekly. SURMOUNT-1: 15mg arm showed ~22.5% weight loss at 72 weeks.
For research and educational use only. This content is not medical advice.