Advanced · 24+ weeks
Retatrutide Maximum Dose Protocol
Full escalation to 12mg weekly target — the maximum dose studied in Phase 2. For GLP-1 experienced researchers who tolerate GI effects. Start at 2mg if prior incretin experience.
- Type
- single
- Source
- evidence-based
- Pattern
- Continuous
Compounds
Retatrutide
SC · Weekly, same day. Target 12mg after full escalation.
SC · Weekly, same day. Target 12mg after full escalation.
12 mg
weekly
weekly
Phases
Initiation (GLP-1 experienced)
Weeks 1-4
Weeks 1-4
2
2mg weekly — can start here if prior GLP-1 experience
2mg weekly — can start here if prior GLP-1 experience
Escalation 1
Weeks 5-8
Weeks 5-8
4
Escalation 2
Weeks 9-12
Weeks 9-12
8
Maximum Dose
Weeks 13+
Weeks 13+
12
12mg weekly — maximum studied dose in Phase 2 (~24% body weight loss)
12mg weekly — maximum studied dose in Phase 2 (~24% body weight loss)
Notes
Only for researchers with prior GLP-1/GIP agonist experience. Significant GI side effects expected during escalation. Monitor electrolytes and hydration carefully.
Source notes
NEJM Phase 2: 12mg arm showed ~24% body weight loss at 48 weeks. r/Retatrutide: some start at 2mg with prior GLP-1 experience.
For research and educational use only. This content is not medical advice.