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Emerging

TB-500

Thymosin Beta-4 Fragment

TB-500 is a synthetic peptide representing the active region of thymosin beta-4, the most abundant actin-sequestering protein in mammalian cells. It is widely studied for its role in cell migration, angiogenesis, and tissue repair processes. TB-500's mechanism — regulating actin polymerization to enable cell movement — makes it fundamentally different from other repair peptides and a mainstay of regenerative research.

Aliases: Thymosin Beta-4 fragment

Research score
7/10
Reality tier
emerging

Key fact

Synthetic fragment of Thymosin Beta-4; promotes systemic tissue repair via actin regulation and cell migration

Mechanism

TB-500 is a synthetic fragment corresponding to the active region of Thymosin Beta-4 (Tβ4), a 43-amino acid naturally occurring peptide. Its primary mechanism involves binding to and sequestering G-actin, modulating actin polymerization which is critical for cell migration, wound healing, and tissue repair. TB-500 promotes: upregulation of cell-building proteins (actin), cell migration to injury sites, blood vessel formation (angiogenesis), downregulation of inflammatory cytokines, and extracellular matrix remodeling with collagen fiber organization. Unlike BPC-157 (which acts locally), TB-500 has systemic reach due to its molecular structure.

Evidence note

Experimental — Strong preclinical data for wound healing and tissue repair. Thymosin Beta-4 itself has been in clinical trials (cardiac, corneal), but TB-500 specifically has no completed human RCTs. Banned by WADA in equine and human sport.

Studies

  • Thymosin β4 activates integrin-linked kinase

    Promoted survival of cardiomyocytes through Akt activation pathways.

    Open source · PMID 17576761

  • Thymosin β4 promotes dermal wound healing

    Accelerated wound closure and keratinocyte migration in dermal injury models.

    Open source · PMID 20618092

  • Thymosin β4 and cardiac repair

    Demonstrated cardioprotective effects and improved cardiac function post-ischemia.

    Open source · PMID 22186258

FAQ

How does it differ from BPC-157?

BPC-157 tends to act locally near the administration site, while TB-500 distributes systemically. Many researchers study both together.

What is TB-500?

A synthetic version of Thymosin Beta-4, a naturally occurring peptide involved in cell migration, tissue repair, and inflammation regulation.

What purity is guaranteed?

Every batch is third-party tested to ≥99% purity. Batch-specific COA available for download.

What's the difference between 5mg and 10mg?

Same compound, same purity. 10mg provides double the material for extended protocols.

For research and educational use only. This content is not medical advice.