SLU-PP-332
SLU-PP-332 is a small molecule ERRα (Estrogen-Related Receptor alpha) agonist developed at Saint Louis University. It activates the same nuclear receptor that mediates exercise-induced metabolic adaptations. Research focuses on its ability to shift muscle fiber composition toward fatigue-resistant Type I fibers and enhance mitochondrial biogenesis. Notable for oral bioavailability, making it accessible without injection.
Aliases: Estrogen-Related Receptor alpha
- Research score
- 4/10
- Reality tier
- experimental
Mechanism
SLU-PP-332 agonizes ERRα, a nuclear receptor activated by exercise. This upregulates genes involved in mitochondrial biogenesis, fatty acid oxidation, and Type I muscle fiber specification. It enhances endurance capacity without exercise stimulus.
Evidence note
Very new compound. Single research group (SLU). Animal data only. Not technically a peptide (small molecule).
Studies
ERRα agonism and metabolic programming
Demonstrated muscle fiber type switching and enhanced mitochondrial function through ERRα activation.
Open source · PMID 37556366SLU-PP-332 and exercise mimetic effects
Increased fatigue-resistant muscle fibers and running endurance in sedentary mice without exercise.
Open source · PMID 37729019
FAQ
Is it orally bioavailable?
Yes. SLU-PP-332 is supplied as capsules — no injection required.
Is SLU-PP-332 a peptide?
Technically it's a small molecule, not a peptide. It's included in our catalog because it targets the same exercise-mimetic pathways as MOTS-c and is frequently studied alongside peptide compounds.
For research and educational use only. This content is not medical advice.