BPC-157 — 5mg
109.99€
KPV — 10mg
A three-amino-acid fragment of alpha-MSH studied for the same anti-inflammatory pathways as its parent hormone, and one of the few peptides researchers have found to show activity via the oral route in published models.
134.99€
Excl. btw 134.99€
- In Stock
- Evidence tier: Experimental
- Format: Lyophilized
- Purity: 99.3%
- Vial size: 10mg
Uitsluitend voor laboratoriumonderzoek. Niet voor gebruik bij mens of dier.
Over KPV
KPV is a synthetic tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH). It retains the anti-inflammatory activity of the full α-MSH molecule while eliminating its melanogenic (skin-darkening) effects. Published research documents KPV's ability to modulate NF-κB signaling — the master inflammatory transcription factor — making it one of the most targeted anti-inflammatory peptides available for research.
KPV is a synthetic tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH). It retains the anti-inflammatory activity of the full α-MSH molecule while eliminating its melanogenic (skin-darkening) effects. Published research documents KPV's ability to modulate NF-κB signaling — the master inflammatory transcription factor — making it one of the most targeted anti-inflammatory peptides available for research.
KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-melanocyte stimulating hormone (alpha-MSH, amino acids 11-13). Despite its small size, it retains the full anti-inflammatory activity of the parent hormone. KPV is transported into intestinal epithelial cells via the peptide transporter PepT1, where it inhibits NF-kB activation, reducing pro-inflammatory cytokine production (TNF-alpha, IL-8). It also modulates immune cell function (reduces nitric oxide production in microglia, inhibits TNF-alpha in astrocytes). In mouse colitis models, orally delivered KPV significantly reduced disease severity. Its small size gives it favorable pharmacokinetic properties including oral bioavailability (unusual for peptides).
Duidelijkheid van het mechanisme: Partially characterized
Tags
Belangrijkste punten
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Onderzoeksscore 5/10
100+ gepubliceerde studies in de dataset
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Bewijsniveau: Experimental
Experimental — Strong preclinical data for colitis and inflammation. The PepT1 transport mechanism is well-published. No completed human RCTs. However, the alpha-MSH anti-inflammatory pathway is well-established in human physiology.
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Realiteitsniveau: Emerging
Moderate published literature. Strong NF-κB inhibition data. No human clinical trials.
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Gegevens bij mensen
None
Opslag en hantering
Gevriesdroogd poeder: Room temp or refrigerated
Na reconstitutie: Refrigerate, use within 30 days
Veiligheid en beperkingen
Onderzocht voor: Gut inflammation, Skin inflammation, Anti-inflammatory, Autoimmune support, Neuroinflammation
Gemelde aanvang: Gut symptom improvement in 1-2 weeks; skin inflammation effects in 2-4 weeks
Gemelde duur: 4-6 weeks; 200-500mcg SC daily or oral
Meldingen uit de community: Very favorable safety profile due to natural origin (fragment of endogenous α-MSH). Users with IBD/IBS report reduced symptoms. No melanogenic effects unlike full-length α-MSH. Caution advised with active melanoma (melanocortin pathway). One of few peptides with documented oral bioactivity.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Kwaliteit en specificaties
Product details
- Productcode
- L-KPV-10
- Beschikbaarheid
- In Stock
- Evidence tier
- Experimental
- Format
- Lyophilized
- Purity
- 99.3%
- Vial size
- 10mg
Reconstitutiereferentie
- Bacteriostatisch water
- 2 mL
- Concentratie
- 50mcg per unit. 500mcg dose = 10 units.
- Spuit
- 29-31G insulin
Onderzoeksparameters
- Standaardhoeveelheid
- 500 µg
- Alternatieve hoeveelheid
- 200 µg
- Flacon
- 10 mg
- Schatting uit de dataset
- 1 vial lasts ~3 weeks at 500mcg/day
Laboratoriumrapport
- Laboratorium
- Janoshik Analytical
- Testdatum
- 2026-03-01
- Document
- Pdf niet bijgevoegd
Bekijk de wetenschap
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PMID 15659637
Lees de studie: KPV tripeptide and anti-inflammatory activity (opent in een nieuw tabblad)
KPV tripeptide and anti-inflammatory activity
Demonstrated significant NF-κB inhibition and anti-inflammatory effects in intestinal epithelial cells.
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PMID 17045821
Lees de studie: Alpha-MSH peptides in colitis treatment (opent in een nieuw tabblad)
Alpha-MSH peptides in colitis treatment
KPV showed therapeutic potential in experimental colitis models.
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PMID 18431481
Lees de studie: PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation (opent in een nieuw tabblad)
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
Orally delivered KPV decreases colitis severity in DSS- and TNBS-induced mouse models via PepT1-mediated transport and NF-kB inhibition.
Studies worden ter referentie vermeld. De meeste zijn uitgevoerd in dier- of celmodellen; de resultaten tonen geen veiligheid of werking bij mensen aan.
Verder lezen
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 2-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
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7 months agor/MCAS · Post
KPV … KPV & GHK-Cu (injections) have helped me … KPV has helped me dramatically
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8 months agor/Biohackers · Post
KPV … I started taking KPV subq 250 mcg once daily at night. … I feel very fatigued and almost like a low grade common cold symptoms every day since I started.
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5 months agor/BodyHackGuide · Post
KPV … I started KPV 5 days ago … I have been feeling nauseous every day since
Based on 3 qualifying reports from 3 threads. 35 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Vragen over KPV
Vragen en antwoorden die bij dit product zijn vastgelegd.
Yes. KPV is one of the few peptides with documented oral bioactivity. Published research shows it crosses the intestinal epithelium via PepT1 transport, making it uniquely suited for gut-targeted anti-inflammatory applications. Both injectable and oral forms are studied.
No. Unlike full-length α-MSH or Melanotan, KPV retains anti-inflammatory properties without melanogenic effects.
A tripeptide (three amino acids: Lys-Pro-Val) derived from alpha-MSH, studied for anti-inflammatory properties.
Beoordelingen
Er zijn nog geen beoordelingen voor dit product.
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