BPC-157 — 5mg
109.99€
The sole cathelicidin antimicrobial peptide in the human immune system, capable of forming physical pores in bacterial membranes.
139.99€
Excl. btw 139.99€
Uitsluitend voor laboratoriumonderzoek. Niet voor gebruik bij mens of dier.
LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans. It is produced by immune cells, epithelial cells, and other tissues as a first-line defense against pathogens. Beyond direct antimicrobial activity, published research documents LL-37's roles in immune cell recruitment, inflammation modulation, wound healing, and biofilm disruption. It sits at the intersection of antimicrobial defense and tissue repair — two processes the body rarely separates.
LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans. It is produced by immune cells, epithelial cells, and other tissues as a first-line defense against pathogens. Beyond direct antimicrobial activity, published research documents LL-37's roles in immune cell recruitment, inflammation modulation, wound healing, and biofilm disruption. It sits at the intersection of antimicrobial defense and tissue repair — two processes the body rarely separates.
LL-37 is the sole human cathelicidin antimicrobial peptide, a 37-amino acid alpha-helical peptide derived from proteolytic cleavage of the 18kDa precursor hCAP-18. It operates through multiple mechanisms: direct antimicrobial action via membrane disruption (oligomerizes to form transmembrane pores in bacterial membranes), LPS/endotoxin neutralization, chemotaxis of immune cells (neutrophils, monocytes, T-cells), inhibition of neutrophil apoptosis, stimulation of angiogenesis and tissue regeneration, and modulation of cytokine release (IL-8, TNF-alpha). Its production is upregulated by vitamin D3, bacterial products, and inflammation.
Duidelijkheid van het mechanisme: Well-characterized
200+ gepubliceerde studies in de dataset
Experimental — Well-characterized as a natural immune peptide with extensive in-vitro and animal data. Clinical research ongoing for wound healing and infection. No completed human RCTs for injectable use. The mechanism is well-established but therapeutic application is early-stage.
Good mechanistic understanding. Antimicrobial + wound healing data. Limited clinical application studies.
In-vitro human cell data
Gevriesdroogd poeder: Room temp or refrigerated
Na reconstitutie: Refrigerate, use within 30 days
Onderzocht voor: Immune defense, Biofilm disruption, Wound healing, Chronic infections, Antimicrobial defense
Gemelde aanvang: Immune effects within days; chronic infection management over 2-4 weeks
Gemelde duur: 2-4 weeks; 100-200mcg SC daily
Meldingen uit de community: Niche peptide used mainly in chronic illness communities (Lyme, long COVID, CFS). Positive reports for chronic infection management. Key concern: LL-37 overexpression is implicated in psoriasis and lupus, so use should be time-limited. Contraindicated in active autoimmune conditions. Low doses recommended — this is potent.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
LL-37, the only human member of the cathelicidin family
Comprehensive review of LL-37's antimicrobial, immunomodulatory, and wound healing properties.
Cathelicidin antimicrobial peptide in wound healing
LL-37 promotes wound vascularization and re-epithelialization.
Cathelicidin LL-37: a multitask antimicrobial peptide
LL-37 is antimicrobial, chemoattractant, anti-apoptotic, and angiogenic; production is regulated by vitamin D3.
Studies worden ter referentie vermeld. De meeste zijn uitgevoerd in dier- of celmodellen; de resultaten tonen geen veiligheid of werking bij mensen aan.
LL-37 … what worked for me is LL-37 … I might have actually beaten chronic bad breath
Based on 1 qualifying reports from 1 threads. 12 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Vragen en antwoorden die bij dit product zijn vastgelegd.
LL-37 interferes with bacterial quorum sensing (communication) and destabilizes the extracellular matrix that protects biofilm communities. Published research shows LL-37 can penetrate and disrupt established biofilms at concentrations where conventional antibiotics fail.
LL-37 has direct antimicrobial activity (kills bacteria) in addition to immune signaling, unlike purely signaling peptides like Thymosin Alpha-1.
The only cathelicidin antimicrobial peptide produced by the human body. It serves as part of the innate immune defense system.
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