MOTS-c — 10mg
189.99€
SS-31 — 10mg
A tetrapeptide that concentrates over 1,000-fold inside mitochondria by binding cardiolipin, the lipid that holds the inner membrane's energy-producing machinery together.
199.99€
Prijs per flacon · Excl. btw 199.99€
- In Stock
- Evidence tier: Emerging
- Format: Lyophilized
- Purity: 99.3%
- Vial size: 10mg
Uitsluitend voor laboratoriumonderzoek. Niet voor gebruik bij mens of dier.
Over SS-31
SS-31 (elamipretide) is a synthetic tetrapeptide that selectively concentrates in the inner mitochondrial membrane, where it interacts with cardiolipin — a phospholipid essential for electron transport chain function. It is the most advanced mitochondrial-targeted peptide in clinical development, with published data from multiple Phase 2 and Phase 3 trials. Researchers study SS-31 because it addresses mitochondrial dysfunction at the structural level, not just the signaling level.
SS-31 (elamipretide) is a synthetic tetrapeptide that selectively concentrates in the inner mitochondrial membrane, where it interacts with cardiolipin — a phospholipid essential for electron transport chain function. It is the most advanced mitochondrial-targeted peptide in clinical development, with published data from multiple Phase 2 and Phase 3 trials. Researchers study SS-31 because it addresses mitochondrial dysfunction at the structural level, not just the signaling level.
SS-31 (D-Arg-Dmt-Lys-Phe-NH2, also known as elamipretide/MTP-131/Bendavia) is a synthetic tetrapeptide that concentrates >1,000-fold in mitochondria due to electrostatic attraction between its positively charged arginine/lysine residues and negatively charged cardiolipin in the inner mitochondrial membrane (IMM). It stabilizes cardiolipin-dependent cristae structure, enhances electron transport chain (ETC) efficiency (particularly Complex III and IV), improves cytochrome c electron-carrying activity while reducing its peroxidase activity, scavenges reactive oxygen species, increases ATP production, and inhibits mitochondrial permeability transition pore (mPTP) opening. This prevents calcium overload and cytochrome c release (anti-apoptotic).
Duidelijkheid van het mechanisme: Well-characterized
Tags
Belangrijkste punten
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Onderzoeksscore 8/10
300+ gepubliceerde studies in de dataset
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Bewijsniveau: Emerging
Emerging — Active clinical trials (Barth syndrome Phase 2/3, heart failure, kidney disease). Published in top journals (PNAS, Nature, eLife). Mechanism is well-characterized. Not yet FDA-approved but multiple clinical programs running. More human data than most peptides on this list (excluding approved ones).
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Gegevens bij mensen
Phase 2/3 clinical trials
Opslag en hantering
Gevriesdroogd poeder: Room temp or refrigerated
Na reconstitutie: Refrigerate, use within 28 days
Veiligheid en beperkingen
Onderzocht voor: Mitochondrial function, Anti-aging, Energy restoration, Cardiac support, Neuroprotection
Gemelde aanvang: Initial fatigue common in first 1-2 weeks (resolves); energy improvements by weeks 3-4
Gemelde duur: 4-8 weeks; 2-5mg SC daily, 5 days on/2 off
Meldingen uit de community: Initial fatigue/malaise is the most-discussed side effect — community recommends methyl donor supplementation (B12, betaine, glycine). After the adaptation period, users report significant energy improvements. Commonly paired with MOTS-c and NAD+. One user on r/BodyHackGuide called high-dose SS-31 + Epithalon 'best decision I ever made.'
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Kwaliteit en specificaties
Product details
- Productcode
- L-SS31-10
- Beschikbaarheid
- In Stock
- Evidence tier
- Emerging
- Format
- Lyophilized
- Purity
- 99.3%
- Vial size
- 10mg
Reconstitutiereferentie
- Bacteriostatisch water
- 2 mL
- Concentratie
- 50mcg per unit (0.01mL). 2mg dose = 40 units.
- Spuit
- 29-31G insulin
Onderzoeksparameters
- Standaardhoeveelheid
- 2000 µg
- Alternatieve hoeveelheid
- 5000 µg
- Flacon
- 10 mg
- Schatting uit de dataset
- 1 vial lasts ~1 week at 2mg/day (5 on/2 off)
Laboratoriumrapport
- Laboratorium
- Janoshik Analytical
- Testdatum
- 2026-03-01
- Document
- Pdf niet bijgevoegd
Bekijk de wetenschap
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PMID 19064528
Lees de studie: SS-31 and mitochondrial dysfunction (opent in een nieuw tabblad)
SS-31 and mitochondrial dysfunction
Restored mitochondrial function and reduced oxidative stress in aged cardiac tissue.
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PMID 26675167
Lees de studie: Elamipretide in heart failure (opent in een nieuw tabblad)
Elamipretide in heart failure
Improved cardiac function in heart failure patients in Phase II clinical trials.
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PMID 32817602
Lees de studie: Mitochondrial protein interaction landscape of SS-31 (PNAS) (opent in een nieuw tabblad)
Mitochondrial protein interaction landscape of SS-31 (PNAS)
SS-31 primarily interacts with cardiolipin in the inner mitochondrial membrane; comprehensive interaction map reveals direct ETC stabilization.
Studies worden ter referentie vermeld. De meeste zijn uitgevoerd in dier- of celmodellen; de resultaten tonen geen veiligheid of werking bij mensen aan.
Verder lezen
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 10-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
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1 year agor/cfs · Post
I've been taking SS-31 for about 4-5 months with some minor breaks. … My primary reason for taking it is to improve egg quality during IVF .
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11 months agor/cfs · Post
SS31 … injecting … this feeling returned, again 3 hours after injection, but intensified
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10 months agor/Peptides · Post
I started today on ss-31 today knowing I'm very sensitive to substances, so decided to start on 0.1mg. … I feel a bit of restlessness and the weird part it feels like I can inhale more air...kind of like as if my air passage has widened.
Based on 3 qualifying reports from 3 threads. 32 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Vragen over SS-31
Vragen en antwoorden die bij dit product zijn vastgelegd.
The initial fatigue/malaise effect is well-documented in the community and typically lasts 1-2 weeks before resolving. It may relate to mitochondrial remodeling as dysfunctional mitochondria are cleared. Community recommends methyl donor supplementation (B12, betaine, glycine) and starting at lower doses (2mg/day).
Both target mitochondria but through different mechanisms. SS-31 stabilizes the electron transport chain directly, while MOTS-c activates AMPK and metabolic pathways.
Yes. As elamipretide, it is in clinical trials for Barth syndrome and other mitochondrial diseases. It has FDA Rare Pediatric Disease and Breakthrough Therapy designations.
Beoordelingen
Er zijn nog geen beoordelingen voor dit product.
Gerelateerde producten
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NAD+ — 500mg
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GHK-Cu — 100mg
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Epithalon — 10mg
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SS-31 — 50mg
599.99€
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