Ipamorelin — 10mg
159.99€
Sermorelin Acetate — 10mg
The first 29 amino acids of your body's own growth hormone-releasing hormone, retaining full biological activity while preserving the pituitary feedback loop that exogenous GH shuts down.
234.99€
Excl. btw 234.99€
- In Stock
- Evidence tier: Established
- Format: Lyophilized
- Purity: 99.4%
- Vial size: 10mg
Uitsluitend voor laboratoriumonderzoek. Niet voor gebruik bij mens of dier.
Over Sermorelin Acetate
Sermorelin acetate is a synthetic peptide consisting of the first 29 amino acids of human growth hormone-releasing hormone (GHRH 1-29). It is the shortest fully functional fragment of GHRH and has been extensively studied for its ability to stimulate natural, pulsatile growth hormone release from the pituitary. With decades of published clinical data, sermorelin remains the benchmark GHRH analog for growth hormone axis research.
Sermorelin acetate is a synthetic peptide consisting of the first 29 amino acids of human growth hormone-releasing hormone (GHRH 1-29). It is the shortest fully functional fragment of GHRH and has been extensively studied for its ability to stimulate natural, pulsatile growth hormone release from the pituitary. With decades of published clinical data, sermorelin remains the benchmark GHRH analog for growth hormone axis research.
Sermorelin is a synthetic 29-amino acid peptide corresponding to the N-terminal segment of GHRH(1-44) that retains full biological activity at GHRH receptors. It stimulates GH gene transcription, increases pituitary GH reserve, and promotes pulsatile GH secretion by activating GHRH-R on somatotrophs via cAMP/PKA signaling. Critically, it preserves the hypothalamic-pituitary GH neuroendocrine axis (the first axis to decline with aging). By supporting pituitary function rather than bypassing it, sermorelin maintains physiological feedback mechanisms including somatostatin regulation.
Duidelijkheid van het mechanisme: Well-characterized
Tags
Belangrijkste punten
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Onderzoeksscore 9/10
284+ gepubliceerde studies in de dataset
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Bewijsniveau: Established
Established — Previously FDA-approved (Geref). Extensive clinical data. Most widely prescribed peptide in anti-aging medicine via compounding pharmacies. Well-understood mechanism with decades of use.
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Gegevens bij mensen
Previously FDA-approved (Geref); extensive clinical data in aging and GH deficiency
Opslag en hantering
Gevriesdroogd poeder: Room temperature or refrigerated
Na reconstitutie: Refrigerate; use within 30 days
Veiligheid en beperkingen
Onderzocht voor: Anti-aging and GH optimization, Sleep quality improvement, Body composition improvement, Recovery from exercise, Energy and vitality enhancement
Gemelde aanvang: Sleep improvement within 1-2 weeks; body composition changes over 2-3 months
Gemelde duur: 3-6 months; 200-500mcg SC daily before bedtime
Meldingen uit de community: Considered the 'safe, boring, reliable' GH peptide. Anti-aging clinic staple. Users report gradual improvements in sleep, skin quality, and body composition over 2-3 months. Natural feedback prevents GH excess. Often recommended as starting point before moving to ipamorelin or CJC combinations.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Kwaliteit en specificaties
Product details
- Productcode
- L-SERM-10
- Beschikbaarheid
- In Stock
- Evidence tier
- Established
- Format
- Lyophilized
- Purity
- 99.4%
- Vial size
- 10mg
Reconstitutiereferentie
- Bacteriostatisch water
- 2 mL
- Concentratie
- 5mg/mL (5mcg per unit). Standard 300mcg dose = 60 units (0.06mL).
- Spuit
- 29-31G insulin
Onderzoeksparameters
- Standaardhoeveelheid
- 300 µg
- Alternatieve hoeveelheid
- 500 µg
- Flacon
- 10 mg
- Schatting uit de dataset
- ~4.7 weeks at 300mcg/day (1 vial of 10mg)
Laboratoriumrapport
- Laboratorium
- Janoshik Analytical
- Testdatum
- 2026-03-01
- Document
- Pdf niet bijgevoegd
Bekijk de wetenschap
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PMID 11337753
Lees de studie: GHRH analogs in aging (opent in een nieuw tabblad)
GHRH analogs in aging
Sermorelin increased IGF-1 and improved body composition markers in older adults.
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PMID 9467534
Lees de studie: Sermorelin and growth hormone deficiency (opent in een nieuw tabblad)
Sermorelin and growth hormone deficiency
Demonstrated effective GH stimulation with preserved physiological pulsatility.
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PMID 19528064
Lees de studie: Sermorelin: a better approach to management of adult-onset GH insufficiency (opent in een nieuw tabblad)
Sermorelin: a better approach to management of adult-onset GH insufficiency
Sermorelin stimulates GH gene transcription, preserves the GH neuroendocrine axis, and maintains pituitary reserve — advantages over exogenous GH replacement.
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Sermorelin and pituitary reserve in aging
Preserves GH axis during aging better than exogenous GH. Pulsatile GH release pattern maintained, supporting physiological feedback mechanisms including somatostatin regulation.
Studies worden ter referentie vermeld. De meeste zijn uitgevoerd in dier- of celmodellen; de resultaten tonen geen veiligheid of werking bij mensen aan.
Verder lezen
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 10-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
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6 months agor/BodyHackGuide · Post
Sermorelin … started taking sermorelin … massive difference in sleep, mood, energy levels, and performance in the gym
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1 year agor/PeptideForum · Post
Semorelin … I have been on Semorelin since March 2024 … fat loss, muscle growth, increased strength and stamina, more clarity in my thoughts, and just a more positive attitude
Based on 2 qualifying reports from 2 threads. 47 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Vragen over Sermorelin Acetate
Vragen en antwoorden die bij dit product zijn vastgelegd.
Sermorelin works through the GHRH receptor pathway, while ipamorelin works through the ghrelin/GHS receptor pathway — two completely different mechanisms for stimulating GH release. Sermorelin has deeper clinical data (previously FDA-approved) and is considered more established. Ipamorelin is more selective with fewer side effects. Many researchers study both together for synergistic GH release through dual-pathway stimulation.
Sermorelin was FDA-approved as Geref Diagnostic in 1997 and withdrawn from the US market in 2008. The withdrawal was for commercial/business reasons (low profitability), NOT for safety concerns. Sermorelin continues to be widely prescribed through compounding pharmacies and remains the most prescribed peptide in anti-aging medicine.
Sermorelin is most commonly administered before bed on an empty stomach (2-3 hours after eating). This timing amplifies the natural nocturnal GH pulse that occurs during deep sleep. Food — particularly carbohydrates and fats — can blunt GH release. Some protocols include up to 1mg nightly for clinical applications.
Sermorelin stimulates your pituitary to release its own GH, preserving natural pulsatile patterns and feedback loops. Exogenous HGH bypasses and suppresses this system.
Yes. Sermorelin acetate was FDA-approved as Geref® for diagnostic evaluation and treatment of growth hormone deficiency. It has one of the strongest clinical track records of any research peptide.
Beoordelingen
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