BPC-157 — 5mg
109.99€
KPV — 10mg
A three-amino-acid fragment of alpha-MSH studied for the same anti-inflammatory pathways as its parent hormone, and one of the few peptides researchers have found to show activity via the oral route in published models.
134.99€
Netto 134.99€
- In Stock
- Evidence tier: Experimental
- Format: Lyophilized
- Purity: 99.3%
- Vial size: 10mg
Wyłącznie do badań laboratoryjnych. Nie do stosowania u ludzi ani zwierząt.
O produkcie KPV
KPV is a synthetic tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH). It retains the anti-inflammatory activity of the full α-MSH molecule while eliminating its melanogenic (skin-darkening) effects. Published research documents KPV's ability to modulate NF-κB signaling — the master inflammatory transcription factor — making it one of the most targeted anti-inflammatory peptides available for research.
KPV is a synthetic tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH). It retains the anti-inflammatory activity of the full α-MSH molecule while eliminating its melanogenic (skin-darkening) effects. Published research documents KPV's ability to modulate NF-κB signaling — the master inflammatory transcription factor — making it one of the most targeted anti-inflammatory peptides available for research.
KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-melanocyte stimulating hormone (alpha-MSH, amino acids 11-13). Despite its small size, it retains the full anti-inflammatory activity of the parent hormone. KPV is transported into intestinal epithelial cells via the peptide transporter PepT1, where it inhibits NF-kB activation, reducing pro-inflammatory cytokine production (TNF-alpha, IL-8). It also modulates immune cell function (reduces nitric oxide production in microglia, inhibits TNF-alpha in astrocytes). In mouse colitis models, orally delivered KPV significantly reduced disease severity. Its small size gives it favorable pharmacokinetic properties including oral bioavailability (unusual for peptides).
Poznanie mechanizmu: Partially characterized
Tagi
Najważniejsze informacje
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Ocena badań 5/10
100+ opublikowanych badań w zbiorze danych
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Poziom dowodów: Experimental
Experimental — Strong preclinical data for colitis and inflammation. The PepT1 transport mechanism is well-published. No completed human RCTs. However, the alpha-MSH anti-inflammatory pathway is well-established in human physiology.
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Poziom praktyczny: Emerging
Moderate published literature. Strong NF-κB inhibition data. No human clinical trials.
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Dane u ludzi
None
Przechowywanie i obchodzenie się
Proszek liofilizowany: Room temp or refrigerated
Po rekonstytucji: Refrigerate, use within 30 days
Bezpieczeństwo i ograniczenia
Badany w kontekście: Gut inflammation, Skin inflammation, Anti-inflammatory, Autoimmune support, Neuroinflammation
Zgłaszany początek działania: Gut symptom improvement in 1-2 weeks; skin inflammation effects in 2-4 weeks
Zgłaszany czas trwania: 4-6 weeks; 200-500mcg SC daily or oral
Relacje społeczności: Very favorable safety profile due to natural origin (fragment of endogenous α-MSH). Users with IBD/IBS report reduced symptoms. No melanogenic effects unlike full-length α-MSH. Caution advised with active melanoma (melanocortin pathway). One of few peptides with documented oral bioactivity.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Jakość i specyfikacja
Product details
- Kod produktu
- L-KPV-10
- Dostępność
- In Stock
- Evidence tier
- Experimental
- Format
- Lyophilized
- Purity
- 99.3%
- Vial size
- 10mg
Dane do rekonstytucji
- Woda bakteriostatyczna
- 2 mL
- Stężenie
- 50mcg per unit. 500mcg dose = 10 units.
- Strzykawka
- 29-31G insulin
Parametry badawcze
- Ilość standardowa
- 500 µg
- Ilość alternatywna
- 200 µg
- Fiolka
- 10 mg
- Szacunek ze zbioru danych
- 1 vial lasts ~3 weeks at 500mcg/day
Raport laboratoryjny
- Laboratorium
- Janoshik Analytical
- Data badania
- 2026-03-01
- Dokument
- PDF nie jest dołączony
Zobacz badania
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PMID 15659637
Czytaj badanie: KPV tripeptide and anti-inflammatory activity (otwiera się w nowej karcie)
KPV tripeptide and anti-inflammatory activity
Demonstrated significant NF-κB inhibition and anti-inflammatory effects in intestinal epithelial cells.
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PMID 17045821
Czytaj badanie: Alpha-MSH peptides in colitis treatment (otwiera się w nowej karcie)
Alpha-MSH peptides in colitis treatment
KPV showed therapeutic potential in experimental colitis models.
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PMID 18431481
Czytaj badanie: PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation (otwiera się w nowej karcie)
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
Orally delivered KPV decreases colitis severity in DSS- and TNBS-induced mouse models via PepT1-mediated transport and NF-kB inhibition.
Badania podano w celach informacyjnych. Większość przeprowadzono na modelach zwierzęcych lub komórkowych; ich wyniki nie dowodzą bezpieczeństwa ani działania u ludzi.
Dalsza lektura
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 2-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
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7 months agor/MCAS · Post
KPV … KPV & GHK-Cu (injections) have helped me … KPV has helped me dramatically
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8 months agor/Biohackers · Post
KPV … I started taking KPV subq 250 mcg once daily at night. … I feel very fatigued and almost like a low grade common cold symptoms every day since I started.
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5 months agor/BodyHackGuide · Post
KPV … I started KPV 5 days ago … I have been feeling nauseous every day since
Based on 3 qualifying reports from 3 threads. 35 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Pytania o KPV
Pytania i odpowiedzi zapisane dla tego produktu.
Yes. KPV is one of the few peptides with documented oral bioactivity. Published research shows it crosses the intestinal epithelium via PepT1 transport, making it uniquely suited for gut-targeted anti-inflammatory applications. Both injectable and oral forms are studied.
No. Unlike full-length α-MSH or Melanotan, KPV retains anti-inflammatory properties without melanogenic effects.
A tripeptide (three amino acids: Lys-Pro-Val) derived from alpha-MSH, studied for anti-inflammatory properties.
Opinie
Ten produkt nie ma jeszcze opinii.
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