BPC-157 — 5mg
109.99€
The first triple-receptor agonist to activate GIP, GLP-1, and glucagon pathways simultaneously, with Phase 2 data showing 24.2% body weight reduction at 48 weeks.
289.99€
Netto 289.99€
Wyłącznie do badań laboratoryjnych. Nie do stosowania u ludzi ani zwierząt.
Retatrutide is the world's first GLP-1/GIP/glucagon triple receptor agonist to enter advanced clinical study. By engaging three distinct metabolic pathways simultaneously, it has generated unprecedented body composition data in published trials. It represents the next evolution beyond dual-agonist peptides like tirzepatide.
Retatrutide is the world's first GLP-1/GIP/glucagon triple receptor agonist to enter advanced clinical study. By engaging three distinct metabolic pathways simultaneously, it has generated unprecedented body composition data in published trials. It represents the next evolution beyond dual-agonist peptides like tirzepatide.
Retatrutide (LY3437943) is a single polypeptide conjugated to a fatty diacid moiety that activates GIP, GLP-1, and glucagon receptors. The triple agonism provides complementary metabolic benefits: GLP-1 reduces appetite and slows gastric emptying, GIP enhances insulin sensitivity and may promote fat storage efficiency, and glucagon receptor activation increases hepatic fat oxidation, energy expenditure, and thermogenesis. The glucagon component also significantly reduces hepatic steatosis, with Phase 2 data showing near-complete resolution of MASLD/MASH in some participants.
Poznanie mechanizmu: Well-characterized triple GIP/GLP-1/glucagon agonism
Phase 2 completed, Phase 3 (TRIUMPH) ongoing opublikowanych badań w zbiorze danych
Emerging — Phase 2 complete with remarkable results (24.2% weight loss). Phase 3 (TRIUMPH program by Eli Lilly) underway. Not yet FDA-approved. Very promising but limited to one major Phase 2 trial published.
Phase 2 RCT with ~300 participants (NEJM published)
Proszek liofilizowany: Room temp or refrigerated
Po rekonstytucji: Refrigerate, use within 30 days
Badany w kontekście: Weight loss, Metabolic syndrome, Prediabetes reversal, NAFLD/MASH, Body recomposition
Zgłaszany początek działania: 2-4 weeks for appetite effects; 8-12 weeks for significant weight loss
Zgłaszany czas trwania: Ongoing; dose escalation monthly from 0.5mg to 12mg
Relacje społeczności: Nausea more common than tirzepatide at higher doses (25%+). GI side effects dose-dependent. Limited community data due to early-stage availability. Clinical trial participants report dramatic weight loss and tolerable side effects.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Triple hormone receptor agonist retatrutide for MASLD
Significant liver fat reduction; potential MASH resolution in Phase 2 participants
Triple-Hormone-Receptor Agonist Retatrutide for Obesity — Phase 2 Trial
Up to 24.2% weight loss at 48 weeks; 72% of prediabetic participants reverted to normoglycemia
Retatrutide — A Game Changer in Obesity Pharmacotherapy
Potent activation of all three receptors (GIP/GLP-1/glucagon); significant weight reduction and metabolic improvements
Badania podano w celach informacyjnych. Większość przeprowadzono na modelach zwierzęcych lub komórkowych; ich wyniki nie dowodzą bezpieczeństwa ani działania u ludzi.
my face most notably returned to pre-trt levels of water retention literally in about 2 weeks
My dosing was: 500 mcg for 5 weeks 750 mcg for 5 weeks 1 mg for 1 week I stopped cold turkey 3 weeks ago with no tapering.Towards the end of the cycle and for a while after stopping, I felt really rough. … Hey everyone,Wanted to share my experience with Retatrutide (reta) in cas…
Based on 2 qualifying reports from 2 threads. 39 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
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Not yet. Phase 2 is complete with remarkable results. Phase 3 (TRIUMPH program by Eli Lilly) is currently underway. It is the most advanced triple agonist candidate in development.
Phase 2 data published in Nature Medicine showed significant liver fat reduction, with near-complete MASLD/MASH resolution in some participants. The glucagon receptor component specifically drives hepatic fat oxidation — an effect unique to triple agonists.
Retatrutide is a triple agonist (GIP + GLP-1 + glucagon) while tirzepatide is a dual agonist (GIP + GLP-1). The added glucagon receptor activation drives hepatic fat oxidation and energy expenditure. Phase 2 data showed up to 24.2% weight loss vs tirzepatide's 22.5% in separate trials.
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