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Emerging

Semax

Synthetic ACTH Analog (4-10)

Synthetic heptapeptide based on the ACTH(4-10) fragment. Approved in Russia as a nootropic since the 1990s. Studied for BDNF expression, cognitive function, and neuroprotection.

Aliases: ACTH(4-10), Semax heptapeptide

Research score
7/10
Reality tier
established

Key fact

Heptapeptide ACTH analog that increases BDNF 3-fold; approved in Russia as prescription nootropic for stroke recovery and cognitive enhancement

Mechanism

Heptapeptide analog of ACTH(4-7) with C-terminal Pro-Gly-Pro extension. Increases BDNF protein levels (1.4-fold) and trkB tyrosine phosphorylation (1.6-fold), upregulates BDNF mRNA (3-fold) and trkB mRNA (2-fold) in hippocampus, modulates serotonergic and dopaminergic neurotransmission, activates MAPK/ERK signaling cascades.

Evidence note

Approved in Russia since 1990s. Multiple animal and human studies on BDNF, cognitive function, and neuroprotection.

Studies

  • Semax neuroprotective effects in ischemia

    Demonstrated neuroprotection and improved cognitive outcomes post-ischemic injury.

    Open source · PMID 16996037

  • Semax and BDNF expression

    Significantly increased BDNF mRNA expression in rat hippocampus and cortex.

    Open source · PMID 17186529

  • Semax prevents learning and memory impairment caused by transient cerebral ischemia

    Semax administration prevented spatial learning and memory impairment in rats following cerebral ischemia, supporting neuroprotective applications.

    Open source · PMID 22036090

FAQ

Is intranasal or subcutaneous administration better for Semax?

Intranasal is the standard route used in Russian clinical practice and most research protocols. It provides rapid onset (5-15 minutes) and bypasses first-pass metabolism. Subcutaneous injection is less common but used by some researchers. The nasal spray format is preferred for convenience and established dosing protocols.

Is Semax injectable?

No. Semax is supplied as a ready-to-use nasal spray — no reconstitution or injections required.

What is Semax approved for?

Semax is an approved prescription medication in Russia for stroke recovery and cognitive disorders. It is sold for research purposes in the US.

For research and educational use only. This content is not medical advice.