MOTS-c — 10mg
189.99€
NAD+ — 500mg
The coenzyme required for 500+ enzymatic reactions in every living cell, with levels that decline approximately 50% between ages 40 and 60.
249.99€
Netto 249.99€
- In Stock
- Evidence tier: Established
- Format: Lyophilized
- Purity: 99.5%
- Vial size: 500mg
Wyłącznie do badań laboratoryjnych. Nie do stosowania u ludzi ani zwierząt.
O produkcie NAD+
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, essential for mitochondrial energy production, DNA repair, sirtuin activation, and hundreds of other enzymatic reactions. NAD+ levels decline significantly with age — by up to 50% between ages 40 and 60 — and this decline is now considered a hallmark of biological aging. Researchers study NAD+ because replenishing cellular NAD+ addresses one of the most upstream and universal mechanisms of age-related decline.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, essential for mitochondrial energy production, DNA repair, sirtuin activation, and hundreds of other enzymatic reactions. NAD+ levels decline significantly with age — by up to 50% between ages 40 and 60 — and this decline is now considered a hallmark of biological aging. Researchers study NAD+ because replenishing cellular NAD+ addresses one of the most upstream and universal mechanisms of age-related decline.
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme in every living cell, participating in 500+ enzymatic reactions. It serves as an electron carrier in mitochondrial oxidative phosphorylation (energy production), a substrate for sirtuins (SIRT1-7, NAD-dependent deacetylases that regulate cellular aging, DNA repair, inflammation, and metabolism), a substrate for PARPs (poly-ADP-ribose polymerases for DNA repair), and a signaling molecule for CD38-mediated calcium signaling. NAD+ declines with age due to increased CD38 activity, decreased NAMPT expression, and increased DNA damage driving PARP consumption. Subcutaneous NAD+ injection bypasses first-pass metabolism and the absorption limitations of oral precursors (NMN, NR).
Poznanie mechanizmu: Well-characterized
Tagi
Najważniejsze informacje
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Ocena badań 8/10
1,284+ opublikowanych badań w zbiorze danych
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Poziom dowodów: Established
Emerging — NAD+ biology is extremely well-established (Nobel Prize-level science). Clinical use of IV NAD+ has decades of history (addiction medicine since the 1960s). Subcutaneous injection is newer but increasingly common via compounding pharmacies. The gap is in rigorous RCTs specifically for SC NAD+ in healthy aging populations.
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Dane u ludzi
Small trials
Przechowywanie i obchodzenie się
Proszek liofilizowany: Room temp or refrigerated
Po rekonstytucji: Refrigerate, use within 30 days
Etapy rekonstytucji ze zbioru danych
- Clean. Remove flip-top cap from NAD+ vial and swab rubber stopper with alcohol.
- Draw water. Draw 2.5mL of bacteriostatic water into syringe.
- Inject water. Insert needle through stopper and slowly inject water down the side of the vial. Do not spray directly onto powder.
- Dissolve. Gently swirl (do not shake) until fully dissolved. Solution should be clear.
- Label. Label vial with date and concentration (200mg/mL). Refrigerate immediately.
- Dose. For 50mg dose: draw 0.25mL (25 units). For 100mg dose: draw 0.5mL (50 units).
Bezpieczeństwo i ograniczenia
Badany w kontekście: Cellular energy, DNA repair, Sirtuin activation, Mitochondrial function, Anti-aging
Zgłaszany początek działania: 1-2 weeks for subjective energy improvement; 4-8 weeks for full protocol effects
Zgłaszany czas trwania: Ongoing supplementation; most protocols reference 4-12 week cycles with breaks
Relacje społeczności: Almost universal stinging at injection site. Users recommend icing before/after. Energy and mental clarity improvements frequently reported within first week. Some report vivid dreams.
For research and educational use only. Source values are reproduced from the current PeptidesEuro content dataset and are not medical advice.
Jakość i specyfikacja
Product details
- Kod produktu
- L-NAD-500
- Dostępność
- In Stock
- Evidence tier
- Established
- Format
- Lyophilized
- Purity
- 99.5%
- Vial size
- 500mg
Dane do rekonstytucji
- Woda bakteriostatyczna
- 2.5 mL
- Stężenie
- 200mg/mL when reconstituted with 2.5mL. 50mg dose = 0.25mL (25 units on insulin syringe).
- Strzykawka
- 29-31G insulin syringe
Parametry badawcze
- Ilość standardowa
- 50000 µg
- Ilość alternatywna
- 100000 µg
- Fiolka
- 500 mg
- Szacunek ze zbioru danych
- ~10 days at 50mg/day (1 vial)
Raport laboratoryjny
- Laboratorium
- Janoshik Analytical
- Data badania
- 2026-03-01
- Dokument
- PDF nie jest dołączony
Zobacz badania
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PMID 24360282
Czytaj badanie: NAD+ and sirtuins in aging (otwiera się w nowej karcie)
NAD+ and sirtuins in aging
Declining NAD+ levels drive age-related sirtuin dysfunction, contributing to metabolic and neurodegenerative disease.
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PMID 29514064
Czytaj badanie: NAD+ supplementation in aging (otwiera się w nowej karcie)
NAD+ supplementation in aging
NAD+ restoration improved mitochondrial function, stem cell renewal, and lifespan in animal models.
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PMID 33037420
Czytaj badanie: NAD+ in human clinical trials (otwiera się w nowej karcie)
NAD+ in human clinical trials
Oral NAD+ precursors safely raised blood NAD+ levels and improved physical performance in older adults.
Badania podano w celach informacyjnych. Większość przeprowadzono na modelach zwierzęcych lub komórkowych; ich wyniki nie dowodzą bezpieczeństwa ani działania u ludzi.
Dalsza lektura
Community evidence
- Source window English Reddit Updated 13 Aug 2026 · 2-year window
- Coverage confidence Low Confidence in the available community sample
- Distribution Pending Not enough data for a distribution.
Selected reports
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1 year agor/NicotinamideRiboside · Post
NAD … I am now taking the injections. … WOW I feel amazing. It's 9:28 PM right now, usually I am bogged down and tired by this time. I feel like I am 20 again.
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4 months agor/NTNPerformance · Post
Injection goes straight in so it’s stronger and you actually feel it more, especially energy wise 1 Continue this thread u/ShaySoda avatar ShaySoda • 2mo ago I mixed the water with the NAD 1ml for every 200mg and when I pinned it burned did anyone else feel this at all 2 u/deadi…
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1 year agor/NicotinamideRiboside · Post
NAD+ … one 50 mg shot of NAD+ … headache for three days
Based on 5 qualifying reports from 5 threads. 28 candidates excluded as duplicates, promotion, deleted content, or lacking concrete personal experience. Reddit self-reports are not medical evidence or proof of causation.
Pytania o NAD+
Pytania i odpowiedzi zapisane dla tego produktu.
NAD+ is the active coenzyme that niacin (B3) is used to produce. Niacin is a precursor; NAD+ is the functional molecule.
NAD+ requires significantly higher doses (750mg vs. 5-10mg for most peptides) and has higher synthesis and stability costs.
Oral precursors (NMN, NR) must be converted to NAD+ in the body, with variable absorption. Direct NAD+ administration bypasses conversion steps. Both approaches have research support.
Opinie
Ten produkt nie ma jeszcze opinii.
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